As filed with the Securities and Exchange Commission on December 27, 2023 Registration No. 333-275316 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to FORM S-1 James Sapirstein, President, Chief Executive Officer and Chairman First Wave BioPharma, Inc. 777 Yamato Road, Suite 502 Boca Raton, Florida 33431 (561) 589-7020 (Name, address, including zip code, and telephone number, including area code, of agent for service) REGISTRATION STATEMENT UNDER THE SECURITIES ACT ...

As filed with the Securities and Exchange Commission on December 18, 2023 Registration No. 333-275316 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FIRST WAVE BIOPHARMA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 46-4993860 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identifica ...

As filed with the Securities and Exchange Commission on November 3, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FIRST WAVE BIOPHARMA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 2834 46-4993860 (I.R.S. Employer Identification Number) 777 Yamato Ro ...

As filed with the Securities and Exchange Commission on July 13, 2023 Registration No. 333-272404 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 3 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FIRST WAVE BIOPHARMA, INC. (State or other jurisdiction of incorporation or organization) (Exact name of registrant as specified in its charter) (Primary Standard Industrial Classification Code Number) Delaware 2834 46-4993860 (I.R.S. Employer Identification ...

As filed with the Securities and Exchange Commission on July 11, 2023 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No.2 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 (Name, address, including zip code, and telephone number, including area code, of agent for service) FIRST WAVE BIOPHARMA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classificati ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 As filed with the Securities and Exchange Commission on July 6, 2023 Registration No. 333-272404 FIRST WAVE BIOPHARMA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 2834 46-4993860 (I.R.S. Employer Identification ...

As filed with the Securities and Exchange Commission on June 5, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FIRST WAVE BIOPHARMA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 2834 46-4993860 (I.R.S. Employer Identification Number) 777 Yamato Road, ...