Question-and-Answer SessionGreat. It's exciting time for Ionis. You have 2 FDA approvals of wholly-owned products in the last 12 months. Commercial launches are underway. One more indication just reported very positive data and then 2 important partner programs read out in large -- for large market readouts next year. And we're privileged to be the first public appearance opportunity after the very exciting CORE and CORE2 data earlier this week. Could you share your perspective where Ionis stands today and ...