TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on June 6, 2023. Registration No. 333-272082 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 TRANSCODE THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) 2834 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Delaware (State or other jurisdiction of incorporation or organization) ...

Washington, D.C. 20549 Amendment No. 1 to FORM S-1 TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on June 5, 2023. Registration No. 333-272082 UNITED STATES SECURITIES AND EXCHANGE COMMISSION REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 TRANSCODE THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) 2834 (I.R.S. Employer Delaware (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) ...

TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on May 19, 2023. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 UNDER THE SECURITIES ACT OF 1933 TRANSCODE THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 2834 (Primary Standard Industrial Classification Code Number) FORM S-1 REGISTRATION STATEMENT 81-1065054 (I.R.S. Employer Identification ...