Table of Contents As filed with the Securities and Exchange Commission on January 7, 2026. Registration No. 333-292283 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Copies to: Siavosh Salimi William A. Magioncalda Paul Hastings LLP The MetLife Building 200 Park Avenue New York, New York 10166 (212) 318-6000 Aktis Oncology, Inc. (Exact name of registrant as specified in its charter) Delaware 2834 85- ...